Will a male breed with a female swordtail when there is 2 other males and another female?

No, Because sWordtail's need to have twice as many females as males. rule is 1 male to 2 female. if you put 1 male with 1 female, the male will harass her and stress will definitely kill her. you setup doesnt look good. you have 3 males to 2 females. you need to buy 4 more females. 3M to 6F ratio, then they will be happy. - mamumami

It is true the ratio of sWordtails should be 2 females or more to 1 male.

From breeding sWordtails for over 25 years I can definitely say it is possible to breed a male and female sWordtail no matter how many of either sex is in the tank. Going with the recommended ratio of males to females will greatly increase your chance of breading sWordtails. TMOCM