What is the difference between liver cancer and hepatomegaly?

Hepatomegaly is a general term meaning enlargement of the liver, but it does not indicate the cause of enlargement. Liver cancer (hepatic carcinoma) is a malignant condition of the liver. There may be enlaregement associated with it, or the cancerous liver may be of normal size. Liver cancer may be primary, meaning that is where the cancer started, or it may be secondary (metastatic) from the spread of a cancer that started elsewhere.