Will vicodin make you fail a pregnancy test?

Vicodin, which contains hydrocodone and acetaminophen, does not affect the results of a pregnancy test. Pregnancy tests detect the hormone human chorionic gonadotropin (hCG) in urine or blood, and Vicodin does not interfere with hCG levels. However, it's important to consult a healthcare provider about any medications taken during pregnancy or if you suspect you might be pregnant.