The region directly affected by the infestation of the boll weevil in the late-19th and early-20th centuries was primarily the southern United States, particularly areas in Texas, Louisiana, Mississippi, Alabama, Georgia, and South Carolina. The boll weevil devastated cotton crops, which were a major economic staple for these states, leading to significant agricultural and economic challenges. The infestation prompted farmers to diversify their crops and adopt new farming practices in response to the crisis.
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