Why does Seroquel overdose cause renal failure?

Seroquel (quetiapine) overdose can lead to renal failure primarily due to its sedative effects and potential for causing severe hypotension, which can reduce renal perfusion and lead to acute kidney injury. Additionally, the overdose may result in metabolic disturbances, such as rhabdomyolysis or dehydration, both of which can further impair kidney function. The accumulation of the drug itself and its metabolites can also be nephrotoxic, exacerbating renal damage. Prompt medical intervention is crucial to mitigate these risks.