What challenges does a lefty face when playing a right-handed guitar?

A left-handed person playing a right-handed guitar may face challenges with hand coordination and finger dexterity, as the dominant hand is typically used for strumming and picking on a right-handed guitar. This can make it harder to learn and play certain techniques. Additionally, the layout of the strings and frets may feel awkward for a left-handed player, requiring extra effort to adapt to the instrument.