To maximize damage with ultimate weapons in Final Fantasy VII, equip the "Mastered" materia, particularly the "Quadra Magic" and "Final Attack" materia. Pair weapons like Cloud's Ultima Weapon, which deals damage based on the number of HP he has, with high-damage spells like "Knights of the Round." Additionally, using the "Enemy Skill" materia to acquire powerful abilities like "Big Guard" for defense and utilizing "Mime" to repeat strong attacks can significantly boost your overall damage output in battles.
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