Why cant i feel my Oxycontin after being on methadone?

Methadone blocks the effects of Oxycontin and other opiates.

Why are you on Methadone and Oxycontin in the first place? And how much of each? Then you will have a more accurate answer than the above.

Well I might not be around to get your answer to my question so here it is:

Methadone is NOT an antagonist acting substance nor even a partial antagonist like SUBUXONE (buprenorphine). Methadone is used as replacement therapy for opiate addicts. It is typically more manageable and longer acting than other opiates.

If you are on both at the same time then you are feeling both of their effects and may have a higher tolerance now (which if you are not on methadone for opiate replacement, then you should talk to your doctor because you are on a quick and horrific road of opiate abuse if this is the case). If you were on Methadone and then switched to Oxycontin, it may be the case that your methadone dosage was stronger than the Oxycontin dosage you took and therefore you now have a higher tolerance.