What were the consequences of the split of Calhoun and Jackson?

There was a flap over the wife of Jackson's Secretary of War, She had been a been a bar-maid and was not considered to be a lady by Mrs Calhoun, who refused to socialize with her. Calhoun also hated the federal tariffs and claimed the right of a state to nullify Federal Laws that it found unacceptable. Jackson did not agree that a state had such a right.