What does the old lady mean when she says what's gone with that boy in Tom Sawyer book?

In Mark Twain's "The Adventures of Tom Sawyer," the old lady is referring to the sudden and mysterious disappearance of Tom Sawyer. By asking "what's gone with that boy," she is inquiring about Tom's whereabouts and expressing concern over his absence. This phrase is a colloquial way of asking where he has gone or what has happened to him.