Can you shoot 22 250 ammo in a savage 250 3000 rifle?

NO! The 22-250 cartridge is based on a bullet diameter of .224,while the 250-3000 savage cartridge is based on a bullet diameter of .257.both cartridge,s are of different overall length,and the 22-250 cartridge is loaded to a higher operating pressure than the 2500-3000 savage cartridge.In truth you could blow the firearm up in your face.Never attempt to shoot any cartridge in a firearm,other than what is marked on the gun.