To stand underneath the hornets nest to spay them in your tree It is a basketball size nests Is this the safe way to do this?

no it is not when the wasps try to escape the might fly towards you and sting try to spray them when not to much wind is blowing and from the side then go in side your house or an enclosed area wait about ten min. and walk back out side spray once more stand back in case there were a few left , remove the nest and dispose of it properly