What is severe hepatic impairment?

Severe hepatic impairment refers to a significant reduction in liver function, typically classified as Child-Pugh Class C in the Child-Pugh scoring system. This condition can result from chronic liver diseases such as cirrhosis, hepatitis, or liver failure, leading to complications like jaundice, ascites, and coagulopathy. Patients with severe hepatic impairment often require careful monitoring and management, as their ability to metabolize drugs and toxins is greatly diminished, increasing the risk of adverse effects.