Yes, you can replace a 2001 Safari's 4L60E transmission with a 2000 Suburban's 4L60E, as they share similar specifications. However, it is essential to verify that both transmissions have compatible wiring harnesses, connectors, and control systems. Additionally, ensure that the torque converters and other related components are also compatible to avoid any issues during installation. Always consult a professional mechanic if you are unsure about specific compatibility details.
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