Patients should be isolated when diagnosed with Clostridioides difficile (C. diff) infection to prevent the spread of the bacteria, particularly in healthcare settings. Isolation is crucial when the patient exhibits symptoms such as diarrhea, as C. diff is highly contagious and spreads through fecal-oral transmission. It is essential to use contact precautions, including wearing gloves and gowns, and ensuring proper hand hygiene. Isolation should continue until the patient has been asymptomatic for at least 48 hours.
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