Hernán Cortés faced several challenges that hindered his efforts to destroy the Aztec Empire. The lack of sufficient manpower for a direct confrontation against the large Aztec forces was a significant obstacle. Additionally, Cortés's reliance on alliances with indigenous groups, which sometimes proved unreliable, complicated his campaign. Furthermore, the spread of disease among the indigenous population, rather than his military tactics alone, played a crucial role in weakening the Aztecs.
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