What of these artists is particularly known for painting the Madonna?

Artists such as Raphael and Botticelli are particularly renowned for their depictions of the Madonna. Raphael's works, including the "Sistine Madonna," showcase his mastery of composition and emotion in portraying the Virgin Mary. Botticelli's "Madonna of the Pomegranate" is another celebrated example that highlights his distinctive style and attention to detail. Both artists significantly contributed to the representation of the Madonna in Renaissance art.