Is it safe to smoke marijuana while on omeprazole?

I have never had problems, in fact it seems to help the omeprazole take affect better for me, but everyone reacts different.

Yes, you can take Prilosec (omeprazole) with marijuana. You can also take all the other drugs in omeprazole's family, such as Nexium (esomeprazole), Prevacid (lansoprazole), Protonix (pantoprazole), Aciphex (rabeprazole) etc....