Is Fentanyl tough on the kidneys?

Fentanyl itself is not specifically known to be tough on the kidneys; however, its use can lead to complications that may affect kidney function. Opioid use, including fentanyl, can cause respiratory depression, which may lead to decreased oxygen levels and potentially harm the kidneys. Additionally, overdose situations often involve other substances or conditions that can impact kidney health. Therefore, while fentanyl isn't directly harmful to the kidneys, its effects can contribute to kidney issues under certain circumstances.