Does bile have anything to do with anger?

Yes, historically, bile has been associated with anger in the context of ancient medical theories, particularly the four humors in Hippocratic medicine. In this framework, an excess of "yellow bile" was thought to lead to a choleric temperament, characterized by irritability and anger. However, modern science does not support a direct physiological link between bile and emotions like anger, as emotions are primarily regulated by the brain and various neurotransmitters.