How did MDR-TB become resistant to antituberulosis?

MDR-TB, or multidrug-resistant tuberculosis, developed resistance to antituberculosis drugs primarily due to inappropriate or incomplete treatment regimens. Factors such as inconsistent drug supply, inadequate dosing, and patient non-compliance allowed the Mycobacterium tuberculosis bacteria to survive and adapt, leading to mutations that confer resistance. Additionally, the high prevalence of TB in areas with limited healthcare access exacerbates the problem, as it creates environments where these resistant strains can spread. Consequently, the misuse of antibiotics in both TB treatment and other infections has further contributed to the emergence of MDR-TB.