Can you mix lorazepam with Tylenol pm?

I will tell you from personal experience with Valium that since it is notorious for causing bad fatigue, head cloudiness, and, depending on the dosage, potentially extremely poor ability to concentrate and temporary anterograde amnesia while you are on it (as in, somebody can tell you something, and then five minutes later you forget what they said. It's very scary), I would not personally recommend that you combine it with Tylenol PM which relies on diphenhydramine; an antihistamine found in most OTC cold medicines, to help you sleep because antihistamines are also well-known to cause poor concentration, extreme head cloudiness, and sleepiness. They basically both do the same kind of thing to you as far as bad side effects from the sedation of your nervous system. The only difference is that Tylenol PM also relieves pain and Valium doesn't. Also, just a cautionary note: Valium is a benzodiazapine and can become extremely addictive if taken daily for too long, even at a steady prescribed dosage, whereas Tylenol PM would be highly unlikely to cause addiction, but could harm your liver if used daily for too long because of the acetaminophen in it, so just be VERY careful with your usage of either one! In any case, I don't know why you are taking either of these things, but I can't imagine why you would want to actually combine them. That does not sound like a good idea at all.

Source(s):Some pharmacological knowledge and a whole lot of experience with Valium and other sedatives.