Can you use Concerta with LSD?

I wouldn't advise it at all. MDMA is a stimulant and in combination with the concerta will likely significantly increase blood pressure, heart rate, and could result in a heart attack. Also, MDMA effects the release/reuptake of serotonin, as does Lexapro (which is an SSRI). It is possible that this combination could lead to Serotonin Syndrome or at least a longer hangover after taking the MDMA.