What does the code PO300 random misfire mean for a 1996 Buick Roadmaster?

The code PO300 indicates a random or multiple cylinder misfire detected by the vehicle's onboard diagnostics in a 1996 Buick Roadmaster. This means that the engine is misfiring in one or more cylinders, which can lead to poor performance, increased emissions, and potential engine damage if not addressed. Possible causes include faulty spark plugs, ignition coils, fuel delivery issues, or vacuum leaks. It's advisable to diagnose the specific problem to resolve the misfire and restore optimal engine performance.