What are Antibiotics with sulfa?

Antibiotics with sulfa, commonly known as sulfonamides, are a class of antimicrobial agents that contain a sulfonamide group. They work by inhibiting the synthesis of folic acid in bacteria, which is essential for their growth and reproduction. While sulfonamides are effective against a variety of bacterial infections, their use has declined due to the development of resistance and the introduction of more effective antibiotics. Common examples include sulfamethoxazole, often combined with trimethoprim to enhance efficacy.