Can you take Benadryl with depakote?

Benadryl (diphenhydramine) is an antihistamine used to treat allergic reactions, motion sickness, and the dystonic reaction caused by medications like Compazine and Haldol. It can be purchased over the counter, but it is also utilized via IV in the hospital.

Depakote (Valproic acid) is used as an anti-seizure medication, as well as used to treat other conditions such as migraines or Bipolar disorder. It is only available by prescription, given in tablet form and can be given via IV in the hospital.

Both of these medications are depressants of the central nervous system. Occasionally, using them together increases that CNS depression, posing a moderate risk. Therefore, using these drugs at the same time should only be done with the permission of your doctor.