1000 mg vicodin (about 133 extra-strength pills) would stop any human from breathing. Without external breathing help, the subsequent anoxia would cause death. When a person dies his metabolism stops, and the vicodin in the system would stop being converted to vicodin metabolites. Without intervention, the body will decompose naturally, and any vicodin remaining in the system has three possible dispositions: it could be broken down by scavenger organisms like bacteria and invertebrates, it could spontaneously decompose due to, e.g., abiotic oxidation, or it could stay unmodified in the decomposing remains of the body. 1000 mg vicodin will stay in the body approximately forever.
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