Can you overdose on sertraline and zopiclone?

Not unless you're swallowing fistfuls of these pills at a time. Obviously, if you take a whole bottle of either drug (or both together), you will need an ambulance. But if you're just taking normal doses, you'll be fine. I just checked a website devoted to drug interactions, and no, there is absolutely no interaction (not even a mild one) between these two drugs. Furthermore, I have been on clonazepam myself, and I have taken both Tylenol and Advil with it. If you wish to check for yourself, I have included a link to the site.