Can you take amoxicillin and aciphex together?

It is safe to take Prilosec with amoxicillin. There are no drug-drug interactions between the two medications. Prilosec is considered to be one of the very safe drugs on the market, while amoxicillin possess some of the common side effects of antibiotics: Nausea, vomiting or diarrhea, Prilosec will not worsen the side effects when taken with amoxicillin.