When was the last time someone was killed by a spider?

The last confirmed fatality from a spider bite in the United States occurred in 2016 when a man in North Carolina died after being bitten by a brown recluse spider. While spider bites can cause serious reactions, deaths are extremely rare due to effective medical treatments. Globally, fatalities from spider bites are also uncommon, with most bites resulting in mild symptoms. The majority of spider species are harmless to humans.