What is the significance of the treble clef in a 4/4 time signature?

The treble clef in a 4/4 time signature is significant because it indicates that the notes written on the staff are meant to be played in the higher range of pitches. The 4/4 time signature tells musicians that there are four beats in each measure, with the quarter note receiving one beat. This combination of the treble clef and 4/4 time signature helps musicians read and interpret music accurately.