Does methadone come up as a opiate in a urine test?

Actually, the answer below is incorrect. The synthetic nature of the medicine has nothing to do with this.

And Methadone, because of its popularity as a recreational drug these days, is routinely included in drug screens today. And a drug screen doesn't know the reason why a pharmaceutical is being taken, whether for pain or for pleasure. So it IS likely to show up in any screen, but not to worry if it is being taken for a legitimate reason. Before being reported, you would be asked about its legitimacy, and if you could show a medical source for the usage, it would not be reported as a result of the drug screen. That's how it works.