What pain killer will not interfere with depakote?

Acetaminophen (Tylenol) is generally considered a pain reliever that does not interfere with Depakote (valproate). Unlike nonsteroidal anti-inflammatory drugs (NSAIDs), which can interact with Depakote, acetaminophen can be safely used for pain relief in most cases. However, it's always best to consult with a healthcare provider before starting any new medication.