I can only speak from my experience, but yes. I'm on 60mg cymbalta taken once per day and 80mg oxycontin (extended release oxycodone) taken 3 times per day (total 240mg). I also use 100mg lyrica taken twice per day and 20-40mg immediate release oxycodone for breakthrough pain. This is due to spinal nerve damage and neuropathic pain.
That being said, I have taken lorazepam in addition to the above, but only every once in a while, not continuously. And I took the base dose, unfortunately i cannot remember what the 'base' dose of lorazepam is.
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