Disadvantages of a captive breeding program?

I saw this question and its the best one I've seen all day!

Ok so a major problem is that if they don't do it when the animal is young, its already adapted to people giving it its necessities and when it goes into the wild, they have to start taking care of themselves which will eventually lead to death. Once an animal is in captivity long enough there is no hope for that creature but that when they will release it, hope that it finds a mate who will take care of it (extreamly rare but still possible) so that they can continue on a chain.

I don't know if you had this in mind but on topic of endangered animals that only live in captivity now, they will never be able to adapt to the wild again because over time their natural instincts will dull from being constantly taken care of.

I also love the fact that its non biased and gives me a lot to work with.