What is best driving route from Charlotte NC to Gainesville VA?

The best driving route from Charlotte, NC to Gainesville, VA typically involves taking I-77 N to I-81 N, then merging onto I-66 E. This route offers a balance of speed and scenic views as you travel through the Appalachian region. The total distance is approximately 300 miles, and the drive usually takes about 4.5 to 5 hours, depending on traffic and road conditions. Always check for real-time traffic updates before your trip for the best experience.