To drain fuel from a 2001 E-150, first, ensure the vehicle is in a safe location and the engine is off. Locate the fuel pump relay in the fuse box and remove it to prevent the pump from operating. Next, disconnect the fuel line at the fuel filter or fuel rail, using a fuel line disconnect tool if necessary, and have a container ready to catch the fuel as it drains out. Always take proper safety precautions when handling fuel, including working in a well-ventilated area and wearing safety gear.
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