What might have affected Pablo Picassos severe style of representation seen in Les Demoiselles d'Avignon?

A whole lode of things:

the death of his young sister at an early age made him hate God which effected his style to a black and white syle, then a close friend died and he started the 'blue period' also during this time, PP's father sent him to UNI (only 13) he completed a what should take a year to complete 'exam' for entrance, in a week, but because he was with others people much older than him he couldn't settle. He was then sent away to a boarding school.

Then he meet a man who became his friend. He was a really, happy-go-lucky guy and PP started his 'Rose Period'.

Then he meet a guy and together they started cubism