Are zopiclone safe to take with methotrexate?

Zopiclone and methotrexate can be taken together, but it's essential to consult a healthcare provider before combining them. Zopiclone is a sedative used for insomnia, while methotrexate is often prescribed for autoimmune conditions and certain cancers. Combining medications can increase the risk of side effects, and individual health factors may affect safety. Always follow a doctor's advice regarding medication interactions.