To reset the PCM (Powertrain Control Module) code on a Lexus IS300, you can disconnect the car's battery by removing the negative terminal for about 15-30 minutes. This will clear any stored trouble codes. After reconnecting the battery, drive the vehicle for a short distance to allow the PCM to recalibrate. Alternatively, you can use an OBD-II scanner to clear the codes directly from the vehicle's diagnostic system.
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