Could Prednisone cause thinning of the intestine?

Yes, long-term use of prednisone, a corticosteroid, can lead to various gastrointestinal side effects, including thinning of the intestinal lining. This can increase the risk of gastrointestinal complications such as ulcers and perforation. However, such effects are more commonly associated with prolonged use and higher doses. It's essential for patients on prednisone to be monitored by a healthcare professional for any potential side effects.