EF lenses are designed for full-frame cameras, while EF-S lenses are designed for APS-C sensor cameras. EF lenses have a larger image circle, allowing them to work on both full-frame and APS-C cameras. EF-S lenses have a smaller image circle, limiting their compatibility to APS-C cameras only. This affects the overall performance as EF lenses may provide better image quality on full-frame cameras, while EF-S lenses are more compact and lightweight. Compatibility-wise, EF lenses can be used on both full-frame and APS-C cameras, while EF-S lenses are restricted to APS-C cameras only.
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