What is the travel time by car from fort Myers to the Florida keys?

The travel time by car from Fort Myers to The Florida Keys typically ranges from 3.5 to 5 hours, depending on traffic and the specific destination in the Keys. The most common route is via US-41 S and the Overseas Highway (US-1). It's important to consider potential delays, especially during peak travel seasons or holidays. Always check current traffic conditions for the most accurate estimate.