What to do with weeds after spraying with weed killer?

After spraying weeds with weed killer, wait several days to a week for the herbicide to fully take effect and the weeds to die. Once they are brown, dry, and brittle, you can remove them by hand or with garden tools. Be sure to wear gloves and dispose of the dead weeds properly—either in garden waste bins or compost, if the herbicide used is safe for composting. Avoid disturbing the soil too much, as this can bring new weed seeds to the surface. Monitor the area for regrowth, and consider mulching to prevent new weeds from sprouting.