How do you sleep with a blister?

To sleep with a blister, it's important to protect the area to prevent further irritation. Cover the blister with a sterile bandage or blister pad to cushion it and keep it clean. Try to position yourself in a way that minimizes pressure on the blister, such as sleeping on your side or using a pillow for support. If the blister is painful, over-the-counter pain relief may also help you get a better night's sleep.