Will Square D QOT breakers fit into QO panels?

A Sq D QOT breaker is a tandem breaker usually used in home retrofits. It will fit into a QO distribution panel but only in certain positions having a mounting pan rail slot. See related links for more information.

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Probably not. Take out an existing breaker and compare. If you don't know how to safely take out an existing breaker, you shouldn't be messing with a replacement anyway.