What incidents earlier in the novel foreshadowed the killing of curleys wife?

Earlier in the novel, Lennie accidentally killed a puppy by petting it too roughly, which foreshadowed his unintentional killing of Curley's wife. Additionally, Slim mentions that it's better to put down a dog that can't take care of itself, hinting at the future tragedy with Lennie. Lastly, Lennie's obsession with soft things and his lack of understanding of his own strength also foreshadow the tragic event.