How are hormones distributed to tissues and what determines which cells a hormone will affect?

Hormones are distributed to tissues through the bloodstream, where they travel from the glands that produce them to various target organs and cells. The specific effects of a hormone are determined by the presence of specific receptors on target cells; only cells with the appropriate receptor can respond to that hormone. Additionally, the concentration of the hormone in the bloodstream and the sensitivity of the target cells can influence the extent of the hormone's effects.