Which mesoamerican civilizations were conquered by Spanish?

The Spanish conquest primarily targeted the Aztec Empire and the Inca Empire, two of the most prominent Mesoamerican civilizations. The Aztecs, located in present-day Mexico, fell to Hernán Cortés in 1521, while the Inca Empire, situated in the Andes of South America, was conquered by Francisco Pizarro in 1533. Other Mesoamerican groups, such as the Maya, experienced varying degrees of conflict and conquest, but they were not fully conquered in the same manner as the Aztecs and Incas.