Do you need a cdl to drive a business class?

I'm assuming you're referring to the Freightliner FL50/60/70/80/90 or Freightliner M2, both of which have been marketed with the "Business Class" trim package.

What it really amounts to is the Gross Vehicle Weight Rating of the vehicle. If it's 26,001 lbs. or higher GVWR, then yes. If not, then no, unless it's either hauling hazardous materials, or is a bus designed to transport more than 15 persons (including the driver).